注）本分類は参考資料としてまとめたものであり、その運用に当たっては各大学のバイオセフティ委員会や動物実験施設関係者等の協議により、判断するものとする。（アンダーライン：主に実験動物に感染する病原体 *：正常動物との隔離を特に必要とする場合には1ランク上げる）

ウイルス

Class 1

　　　Live vaccine virus (Vaccinia, Rabies, Rinderpest vaccineを除く)

Class 2

BK

Batai

Borna

Bunyamwera

California encephalitis

Canine adeno (Infectious canine hepatitis)

Canine distemper

Canine parvo

Cavid herpes 1(Guinea pig cytomegalo)

Cowpox

Coxsackie （全型）

Dengue （全型）

Echo (全型)

Ectromelia (Mouse pox) *

Encephalomyocarditis (EMC)

Entero (68, 69, 70, 71)

Epstein-Barr (EB)

Feline calici

Feline immunodeficiency

Feline infectious peritonitis

Feline leukemia

Feline panleukopenia

Feline rhinotrachitis

Gibbon ape lymphosarcoma

Hepatitis (A, B, C, D, E)

Herpes papio

Herpes saimiri

Herpes simplex (1, 2)

Human Parvo

Human Rhino

Human Rota

Human T-cell leukemia -lymphoma (HTLV 1, 2)

Human adeno

Human astro

Human calici

Human corona

Human cytomegalo

Human herpes (6, 7, 8)

Human papilloma

Influenza (A, B, C)

JC

Japanese encephalitis

Kilham’s rat

La Crosse

Lactate dehydrogenase-elevating (LDV)

Langat

Measles (SSPEを含む)

Minute virus of mice (MVM)

Monkey pox *

Mouse adeno

Mouse cytomegalo

Mouse encephalomyelitis (TMEV)

Mouse hepatitis *

Mouse polyoma

Mouse rota(EDIM)

Mouse thymic

Mumps

Murine leukemia

Myxoma *

Newcastle disease

Orbi

O’Nnyong-Nnyong

Parainfluenza（1-Sendai*, 2, 3, 4）

Pneumonia virus of mice(PVM)

Polio (1, 2, 3)

Prion disease agents (Creutzfeldt-Jakob, BSE, Scrapie)

Rabbit hemorrhagic disease *

Rabbit parvo

Rabbit pox

Rabbit rota

Rat cytomegalo

Rabies (fixed, live vaccine)

Reo

Respiratory syncytial (RS)

Rinderpest (vaccine strain)

Rio Bravo

Rubella

Sendai (HVJ)*

Sialodacryoadenitis（rat corona）

Simian immunodeficiency (SIV)

Sindbis

Vaccinia

Varicella -Zoster

Vesicular stomatitis

Woodchuck hepatitis

Wooly monkey lymphosarcoma

Yaba monkey tumor pox

　

Class 3

Chikungunya

Colorado tick fever

Eastern equine encephalomyelitis

Hanta (Hemorrhagic fever with renal syndrome (HFRS) )

Herpes ateles

Human immunodeficiency (HIV 1,2)

Kyasanur forest disease

Lymphocytic choriomeningitis (LCM)

Mayaro

Murray valley encephalitis

Negishi

Powassan

Rabies (street strain)

Rift valley fever

Russian Spring-Summer encephalitis

Semliki forest

St. Louis encephalitis

Tacaribe

Tanapox

Tick-borne encephalitis

Venezuelan equine encephalitis (VEE)

Western equine encephalitis (WEE)

West Nile fever

 

Class 4

Crimean Congo hemorrhagic fever

Ebola

Hanta (Hantavirus pulmonary syndrome (HPS))

Herpes B **

Junin

Lassa fever

Machupo

Marburg disease

Variola (major,minor)

Yellow fever (17D vaccine strainを除く)

** : Ｂウイルスの診断のため、少量の培養を含む検査は安全度3の設備で実施できるとの見解が、国立感染症研究所の病原体等安全管理規程に示されている。

 

 

細菌およびマイコプラズマ

（ここにない細菌およびマイコプラズマの分類は、日本細菌学会バイオセフティ指針を参考にする）

 

Class1

Class2およびClass3に属さない細菌

（Class 2あるいはClass 3に近縁種がある場合は、それを参考にして判断する）

 

Class 2

Actinomadura madurae

Actinomadura pelletieri 　　　

Actinomyces bovis

Actinomyces israelii

Actinomyces pyogenes

Actinomyces viscosus

Aeromonas hydrophila(毒素原性株)

Aeromonas sobria(毒素原性株)

Bacillus cereus(毒素原性株)

Bordetella bronchiseptica

Bordetella parapertussis

Bordetella pertussis

Borrelia (全菌種)

Burkholderia cepacia

Calymmatobacterium granulomatis

Campylobacter coli

Campylobacter jejuni

Chlamydia pneumoniae

Chlamydia trachomatis

Cilia-associated respiratory(CAR) bacillus

Clostridium botulinum

Clostridium difficile

Clostridium haemolyticum

Clostridium histolyticum

Clostridium novyi

Clostridium perfringens(毒素原性)

Clostridium piliforme (Tyzzer's organism) *

Clostridium septicum

Clostridium sordelli

Clostridium sporogenes

Clostridium tetani

Corynebacterium diphtheriase

Corynebacterium jeikeium

Corynebacterium kutscheri *

Corynebacterium pseudodiphtheriticum

Citrobacter freundii

Citrobacter rodentium(Escherichia coli O115a,c;K(B))

Erysipelothrix rhusiopathiae

Escherichia coli (E.coli,K12株,B株並びにその誘導体を除く)

Francisella novicida

Fusobacterium necrophorum

Haemophilus(Actinobacillus) actinomycetemcomitans

Haemophilus ducreyi　

Haemophilus influenzae

Helicobacter hepaticus　

Helicobacter pylori

Klebsiella oxytoca

Klebsiella pneumoniase

Legionella 全菌種(Legionella-like organismsを含む)

Leptospira interrogans全血清型

Listeria monocytogenes

Moraxella (Branhamella) catarrhalis

Mycobacterium avium

Mycobacterium chelonae

Mycobacterium fortuitum

Mycobacterium haemophilum

Mycobacterium intracellulare

Mycobacterium kansasii

Mycobacterium leprae

Mycobacterium ulcerans

Mycobacterium lepraemurium

Mycobacterium malmoense

Mycobacterium marinum

Mycobacterium paratuberculosis

Mycobacterium scrofulaceum

Mycobacterium simiae

Mycobacterium szulgai

Mycobacterium xenopi

Mycoplasma arthritidis

Mycoplasma hominis

Mycoplasma neurolyticum

Mycoplasma pneumoniae

Mycoplasma pulmonis *

Neisseria gonorrhoeae

Neisseria meningitidis

Nocardia asteroides

Nocardia brasiliensis

Nocardia farcinica

Nocardia otitidiscaviarum

Pasteurella multocida (動物に疾病をおこす血清型（Class 3 ）を除く)

Pasteurella pneumotropica

Plesiomonas shigelloides　

Pseudomonas aeruginosa

Salmonella (Class 3 を除く全血清型) *

Serattia marcescens

Shigella 全菌種

Staphylococcus aureus

Streptobacillus moniliformis

Streptococcus pneumoniase

Streptococcus pyogenes

Streptococcus zooepidemicus *

Treponema carateum

Treponema cuniculi

Treponema pallidum subsp. pallidum

Treponema pallidum subsp. pertenue

Vibrio cholerae

Vibrio fluvialis

Vibrio mimicus

Vibrio parahaemolyticus

Vibrio vulnificus

Yersinia enterocolitica

Yersinia pseudotuberculosis

 

Class 3

Bacillus anthracis

Brucella (全菌種)

Burkholderia mallei

Burkholderia pseudomallei

Chlamydia psittaci

Coxiella burnetii

Ehrlichia canis

Ehrlichia sennetsu

Francisella tularensis

Mycobacterium africanum

Mycobacterium bovis

Mycobacterium tuberculosis

Orientia tsutsugamushi

Pasteurella multocida (動物に疾病を起こす血清型：B:6, E:6, A:5, A:8, A:9)

Rickettsia spp.

Salmonella serovar paratyphi A

Salmonella serovar typhi

Yersina pestis

 

真菌

 

Class 1

Class 2およびClass 3に属さない真菌

(Class 2あるいはClass 3に近縁種がある場合は、それを参考にして判断する）

 

Class 2

Acremonium kiliense

Allescheria boydii

Arachnia propionica

Aspergillus fumigatus

Aspergillus spp. (毒素産生株)

Candida albicans　

Chaetomium spp. (毒素産生株)

Cladosporium carrionii

Cladosporium trichoides (C. bantianum)

Cryptococcus neoformans

Curvularia geniculata

Dreschslera apiciferum

Expophiala dermatitidis

Fonsecaera pedrosoi

Fusarium spp. (毒素産生株)

Leptosphaeria senegalensis

Madurella grisea

Madurella mycetomii

Microsporum canis

Microsporum gypseum

Mucor sp.

Myrothecium spp. (毒素産生株)

Neotestudina rosatii

Penicillium spp. (毒素産生株)

Phialophora jeanselmei

Pneumocystis carinii * (従来、protozoaとされてきたが、真菌だとする場合もある)

Pyrenochaeta romeroi

Rhizopus sp.

Sporothrix schenckii

Trychophyton mentagrophytes

Trychophyton schoenleinii

Trychophyton simii

Trychophyton verrucosum

 

Class 3

Blastomyces dermatitidis

Coccidioides immitis

Cryptococcus neoformans

Histoplasma capsulatum

Histoplasma duboisii

Histoplasma farciminosum

Paracoccidioides brasiliensis

Penicillium marneffei

　

寄生虫

 

Class 1

Class2およびClass 3に属さない原虫類、吸虫類、条虫類および線虫類

(Class 2あるいはClass 3に近縁種がある場合は、それを参考にして判断する）

 

Class 2

　　　Protozoa

Babesia spp. (ookinete)

Balantidium coli (cyst)

Cryptosporidium spp. (oocyst)

Eimeria spp. (oocyst)　

Encephalitozoon (Nosema) cuniculi (spore)

Giardia spp. (trophozoite, cyst)

Leishmania spp. (promastigote, amastigote) （レベル3に示すものを除く）

Neospora caninum (cyst)

Pentatrichomonas hominis (trophozoite)

Pneumocystis carinii (cyst) *　(従来、protozoaとされてきたが、真菌だとする場合もある)

Sarcocystis spp. (sporocyst, gametocyte)

Spironucleus muris(trophozoite, cyst)

Trichomonas vaginalis (trophozoite)

 

　　　Trematoda

Centrocestus spp. (metacercaria)

Clonorchis sinensis (metacercaria)

Dicrocoelium dendriticum (metacercaria)

Echinostoma spp. (metacercaria)

Echinochasmus perfoliatus (metacercaria)

Fasciola hepatica (metacercaria)

Fasciolopsis buski (metacercaria)

Gigantobilharzia spp. (cercaria)

Heterophyes heterophyes (metacercaria)

Metagonimus yakogawai (metacercaria)

Opistorchis spp. (metacercaria)

Paragonimus spp. (metacercaria)

Plagiorchis muris (metacercaria)

Trichobilharzia spp. (cercaria)

 

　　　Cestoda

Bertiella studeri (cysticercoid)

Diphyllobothrium latum (plerocercoid)

Dipylidium spp. (cysticercoid, procercoid, plerocercoid)

Diplogonoporus grandis (plerocercoid)

Hymenolepis diminuta (cysticercoid)

Raillietina celebensis (cysticercoid)

Taenia spp. (egg, cysticercus)  （レベル3に示すものを除く）

Vampirolepis (Hymenolepis) nana (egg, cysticercoid)

 

　　　Nematoda

Ancylostoma spp. (larva)

Anisakis spp. (larva)

Ascaris lumbricoides (egg)

Aspiculuris tetraptera (egg)

Brugia spp. (larva)

Capillaria hepatica (egg)

Dirofilaria spp. (larva)

Dracunculus medinensis (larva)

Enterobius vermicularis (egg)

Gnathostoma spp. (larva)

Loa loa (larva)

Mansonella perstans (larva)

Necator americanus (larva)

Onchocerca volvulus (larva)

Pseudoterranova decipiens (larva)

Rhabditis spp. (larva)

Syphacia spp. (larva)

Thelazia callipaeda (larva)

Toxocara spp. (egg)

Trichostrongylus orientalis (larva)

Trichuris trichiura (egg)

Wuchereria bancrofti (larva)

 

Class 3

Protozoa

Acanthamoeba (Hartmannella) culbertsoni (trophozoite, cyst)

Entamoeba histolytica (cyst)

Leishmania donovani (promastigote, amastigote)

Leishmania braziliensis (promastigote, amastigote)

Naegleria fowleri (trophozoite, cyst)

Plasmodium falciparum (erythrocytic stage, sporozoite)

Plasmodium malariae (erythrocystic stage, sporozoite)

Plasmodium ovale (erythrocystic stage, sporozoite)

Plasmodium vivax (erythrocystic stage,sporozoite)

Simian malarial parasites (erythrocystic stage, sporozoite)

Toxoplasma gondii (tachyzoite, bradyzoite, oocyst)

Trypanosoma spp. (trypomastigote, amastigote)

 

　　　Trematoda

Schistosoma spp.(cercaria)

 

　　　Cestoda

Echinococcus spp. (egg, hydatid sand)

Taenia solium (egg)

 

　　　Nematoda

Angiostrongylus spp. (larva)

Baylisascaris procyonis (egg)

Capillaria philippinensis (larva)

Strongyloides spp. (larva)

Trichinella spiralis (larva)